Targeted photosensitizer delivery: A prospective approach to vitiligo photochemotherapy

Acral lesions of vitiligo: why are they resistant to photochemotherapy?

BACKGROUND Acral lesions of vitiligo are usually resistant to conventional lines of treatment as well as surgical interventions. OBJECTIVE To clarify causes underlying resistance of acral lesions to pigmentation in vitiligo by studying some of the factors associated with mechanisms of repigmentation following photochemotherapy. METHODS The study included twenty patients with active vitiligo...

A monomeric photosensitizer for targeted cancer therapy.

A targeted photosensitizer used in photodynamic therapy (PDT) was fabricated by incorporation of zinc phthalocyanine (ZnPc) and folic acid (FA) into polyvinylpyrrolidone (PVP) micelles, which exhibits excellent anticancer performance revealed by both in vitro studies and in vivo tests.

Local Drug Delivery –A Targeted Approach

Successful periodontal treatment is dependent on anti-inflammatory procedure which includes both mechanical and chemotherapeutic approach. Chemotherapeutic approach includes local application or sustained release of local drug delivery agents and systemic approaches. Locally delivered antimicrobial agents are administered to prevent plaque accumulation and to disinfect the root surface and adja...

Advances in Targeted Drug Delivery

Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors.

Therapeutic drug delivery across the blood-brain barrier (BBB) is not only inefficient, but also nonspecific to brain stroma. These are major limitations in the effective treatment of brain cancer. Transferrin peptide (Tfpep) targeted gold nanoparticles (Tfpep-Au NPs) loaded with the photodynamic pro-drug, Pc 4, have been designed and compared with untargeted Au NPs for delivery of the photosen...